Spravato® esketamine treatment.
An FDA-approved nasal spray for adults with treatment-resistant depression, administered in our office under continuous medical supervision and the full REMS safety protocol.
Status
FDA-Approved
Format
Esketamine nasal spray
Visit length
~2 hours observed
Setting
REMS-certified clinic
The first FDA-approved nasal spray for treatment-resistant depression.
Spravato® (esketamine) is approved by the FDA for adults whose depression has not responded adequately to other antidepressant medications. It is used in conjunction with an oral antidepressant, not as a replacement for it.
Because Spravato® is a controlled medication with a real safety profile, it can only be administered inside a clinic certified under the FDA's REMS program. Renue is one of those clinics. Every dose is self-administered by you, observed by a clinician, and followed by a structured monitoring period.
Spravato® is for a specific kind of patient.
The label is narrow on purpose. Eligibility is determined by our clinical team during your evaluation, with input from your existing prescriber where helpful.
- Adults age 18 and older
- A diagnosis of major depressive disorder or treatment-resistant depression
- At least two prior antidepressant medications that have not delivered adequate relief
- Willingness to continue an oral antidepressant alongside Spravato®
- Able to remain in clinic for the full monitoring period after each dose
What actually happens when you come in.
- 01
Arrival and check-in
Brief vitals, a quick wellness check, and time to settle into your private suite.
- 02
Self-administration, under supervision
You administer the nasal spray yourself while a clinician is present, in a calm, dimly lit space.
- 03
Two hours of monitoring
We monitor blood pressure and how you are feeling. Many patients close their eyes, listen to music, or simply rest.
- 04
Discharge
Once cleared, you head home. Because Spravato® affects alertness, you will need a ride.
Spravato® is often covered by commercial insurance.
Our team handles the benefits investigation, prior authorization, and REMS coordination on your behalf. You will know what your out-of-pocket cost looks like before you begin treatment.
See how patients pay- How often are treatments?
- Typically twice weekly during the induction phase, then tapering based on response. Your clinician will tailor the schedule to you.
- How quickly might I feel an effect?
- Many patients describe meaningful changes within the first one to four weeks, though response varies.
- Can I drive home afterward?
- No. You must arrange transportation home on treatment days, and you should not operate machinery or make major decisions until the next day.
Medical disclaimer. Treatment decisions are made only after a clinical consultation. Outcomes may vary. Information presented here is educational and not a substitute for medical advice. If you are in crisis, call or text 988. For emergencies, call 911.
Ready to begin?
Request a free consultation and our clinical team will help you understand your options.